Sam Winchester

Jared Padalecki

Dean Winchester

Jensen Ackles

Guest Star

Mercedes McNab

Guest Star

A.J. Buckley

Guest Star

Sandra McCoy

Lisa Braeden

Cindy Sampson

John Winchester

Jeffrey Dean Morgan

Bela Talbot

Lauren Cohan

Guest Star

Billy Drago

Bobby Singer

Jim Beaver

Guest Star

C. Malik Whitfield

Castiel / Emmanuel / Jimmy Novak

Misha Collins

Guest Star

Travis Wester

Guest Star

Sterling K. Brown

Guest Star

Katie Cassidy

Guest Star

Nicholas Elias

Crowley

Mark Sheppard

Tamara

Caroline Chikezie

Guest Star

Matthew Humphreys

Isaac

Peter Macon

Walter Rosen (Envy)

Josh Daughtery

Rowena MacLeod

Ruth Connell

Heavy-Set Man (Sloth)

C. Ernst Harth

Jack / Belphegor

Alexander Calvert

Hot Girl (Lust)

Katya Virshilas

Mary Winchester

Samantha Smith

Bartender (Gluttony)

Michael Rogers

Lucifer

Mark Pellegrino

Bouncer (Wrath)

Gardiner Millar

Arthur Ketch

David Haydn-Jones

Jody Mills

Kim Rhodes

Business Man (Pride)

Ben Cotton

Waitress (Greed)

Tiara Sorenson

Amara / Amara (Adult) / Karin

Emily Swallow

Ruby / Genevieve Padalecki

Genevieve Padalecki

Shopper

Allison Warnyca

Red Head

Monique Ganderton

Metatron

Curtis Armstrong

Gabriel / Trickster

Richard Speight Jr.

Charlie Bradbury

Felicia Day

Billie

Lisa Berry

Eli / Benny Lafitte

Ty Olsson

Naomi

Amanda Tapping

Kelly Kline

Courtney Ford

Donatello Redfield / God

Keith Szarabajka

Adam Milligan / Michael

Jake Abel

Hannah / Caroline Johnson / Young Mother

Erica Carroll

Duma / The Shadow / Robin

Erica Cerra

Samuel Campbell / Shapeshifter

Mitch Pileggi

Zachariah

Kurt Fuller

Ellen Harvelle

Samantha Ferris

Meg Masters

Rachel Miner

Abaddon

Alaina Huffman

Eileen Leahy

Shoshannah Stern

Kevin Tran

Osric Chau

Maggie

Katherine Evans

Jo Harvelle

Alona Tal

Donna Hanscum

Briana Buckmaster

Balthazar

Sebastian Roché

Claire Novak

Kathryn Newton

Liane Balaban

Young Sam Winchester

Colin Ford

Rufus Turner

Steven Williams

Garth Fitzgerald / Garth Fitzgerald

DJ Qualls

Toni Bevell

Elizabeth Blackmore

Anna Milton

Julie McNiven

God

Rob Benedict

Jessica Moore

Adrianne Palicki

Death

Julian Richings

Edgar

Benito Martinez

Ben Braeden

Nicholas Elia

Gadreel / Ezekiel

Tahmoh Penikett

Meg Masters

Nicki Aycox

Mick Davies

Adam Fergus

Pamela Barnes

Traci Dinwiddie

Sister Jo / Anael

Danneel Ackles

Uriel

Robert Wisdom

Michael

Christian Keyes

Asmodeus

Jeffrey Vincent Parise

Alex Jones

Katherine Ramdeen

Kaia Nieves / Dark Kaia

Yadira Guevara-Prip

Ash

Chad Lindberg