Sam Winchester

Jared Padalecki

Dean Winchester

Jensen Ackles

Castiel / Jimmy Novak / Emmanuel

Misha Collins

Lisa Braeden

Cindy Sampson

Guest Star

Andrew Rothenberg

Guest Star

Katie Walder

Ben Braeden

Nicholas Elia

Guest Star

Julian Richings

Bobby Singer

Jim Beaver

Guest Star

Sam Hennings

Meg Masters

Rachel Miner

Samuel Campbell / Shapeshifter

Mitch Pileggi

Guest Star

Mark A. Sheppard

Guest Star

Julia Maxwell

Guest Star

Sebastian Roche

Mary Winchester

Samantha Smith

Guest Star

Jessica Heafey

Rowena MacLeod

Ruth Connell

Jack / Belphegor

Alexander Calvert

Lucifer

Mark Pellegrino

Arthur Ketch

David Haydn-Jones

Jody Mills

Kim Rhodes

Amara / Amara (Adult) / Karin

Emily Swallow

Ruby / Genevieve Padalecki

Genevieve Padalecki

Metatron

Curtis Armstrong

Gabriel / Trickster

Richard Speight Jr.

Charlie Bradbury

Felicia Day

John Winchester

Jeffrey Dean Morgan

Billie

Lisa Berry

Eli / Benny Lafitte

Ty Olsson

Naomi

Amanda Tapping

Kelly Kline

Courtney Ford

Kevin Tran

Osric Chau

Donatello Redfield / God

Keith Szarabajka

Ellen Harvelle

Samantha Ferris

Adam Milligan / Michael

Jake Abel

Hannah / Caroline Johnson / Young Mother

Erica Carroll

Duma / The Shadow / Robin

Erica Cerra

Jo Harvelle

Alona Tal

Zachariah

Kurt Fuller

Liane Balaban

Abaddon

Alaina Huffman

Eileen Leahy

Shoshannah Stern

Maggie

Katherine Evans

Donna Hanscum

Briana Buckmaster

Claire Novak

Kathryn Newton

Young Sam Winchester

Colin Ford

Rufus Turner

Steven Williams

Garth Fitzgerald / Garth Fitzgerald

DJ Qualls

Toni Bevell

Elizabeth Blackmore

Anna Milton

Julie McNiven

Bela Talbot

Lauren Cohan

Ruby

Katie Cassidy

God

Rob Benedict

Jessica Moore

Adrianne Palicki

Edgar

Benito Martinez

Gadreel / Ezekiel

Tahmoh Penikett

Meg Masters

Nicki Aycox

Mick Davies

Adam Fergus

Pamela Barnes

Traci Dinwiddie

Sister Jo / Anael

Danneel Ackles

Uriel

Robert Wisdom

Michael

Christian Keyes

Asmodeus

Jeffrey Vincent Parise

Alex Jones

Katherine Ramdeen

Kaia Nieves / Dark Kaia

Yadira Guevara-Prip

Ash

Chad Lindberg