Sam Winchester

Jared Padalecki

Dean Winchester

Jensen Ackles

Mike

Brandon Jones

Guest Star

Hal Linden

Guest Star

Christian Campbell

Guest Star

John Reardon

Guest Star

Jon Gries

Charlie Bradbury

Felicia Day

Guest Star

Gil McKinney

Guest Star

D.J. Qualls

Guest Star

Osric Chau

Guest Star

Madison McLaughlin

Guest Star

Leigh Parker

Kate

Britni Sheridan

Guest Star

Adrian Hough

Guest Star

John DeSantis

Castiel / Emmanuel / Jimmy Novak

Misha Collins

Guest Star

Anna Van Hooft

Guest Star

Tiffany Dupont

Guest Star

Lauren Tom

Guest Star

Mishael Morgan

Guest Star

Patrick Stafford

Guest Star

Brandon W. Jones

Guest Star

Curtis Armstrong

Sheriff

Paul Belsito

Guest Star

Mark Sheppard

Guest Star

Assaf Cohen

Guest Star

Adam Rose

Meg Masters

Rachel Miner

Guest Star

Liane Balaban

Guest Star

Taylor Cole

Bobby Singer

Jim Beaver

Guest Star

Amanda Tapping

Eli / Benny Lafitte

Ty Olsson

Guest Star

Graham Wardle

Rowena MacLeod

Ruth Connell

Guest Star

Alaina Huffman

Guest Star

Cindy Busby

Jack / Belphegor

Alexander Calvert

Mary Winchester

Samantha Smith

Guest Star

Kim Rhodes

Lucifer

Mark Pellegrino

Arthur Ketch

David Haydn-Jones

Amara / Amara (Adult) / Karin

Emily Swallow

Ruby / Genevieve Padalecki

Genevieve Padalecki

Gabriel / Trickster

Richard Speight Jr.

John Winchester

Jeffrey Dean Morgan

Lisa Braeden

Cindy Sampson

Billie

Lisa Berry

Kelly Kline

Courtney Ford

Donatello Redfield / God

Keith Szarabajka

Adam Milligan / Michael

Jake Abel

Hannah / Caroline Johnson / Young Mother

Erica Carroll

Duma / The Shadow / Robin

Erica Cerra

Samuel Campbell / Shapeshifter

Mitch Pileggi

Zachariah

Kurt Fuller

Ellen Harvelle

Samantha Ferris

Eileen Leahy

Shoshannah Stern

Maggie

Katherine Evans

Jo Harvelle

Alona Tal

Donna Hanscum

Briana Buckmaster

Balthazar

Sebastian Roché

Claire Novak

Kathryn Newton

Young Sam Winchester

Colin Ford

Rufus Turner

Steven Williams

Toni Bevell

Elizabeth Blackmore

Anna Milton

Julie McNiven

Bela Talbot

Lauren Cohan

Ruby

Katie Cassidy

God

Rob Benedict

Jessica Moore

Adrianne Palicki

Death

Julian Richings

Edgar

Benito Martinez

Ben Braeden

Nicholas Elia

Gadreel / Ezekiel

Tahmoh Penikett

Meg Masters

Nicki Aycox

Mick Davies

Adam Fergus

Pamela Barnes

Traci Dinwiddie

Sister Jo / Anael

Danneel Ackles

Uriel

Robert Wisdom

Michael

Christian Keyes

Asmodeus

Jeffrey Vincent Parise

Alex Jones

Katherine Ramdeen

Kaia Nieves / Dark Kaia

Yadira Guevara-Prip

Ash

Chad Lindberg