Sam Winchester

Jared Padalecki

Dean Winchester

Jensen Ackles

Crowley

Mark Sheppard

Castiel

Misha Collins

Guest Star

David Hoflin

Guest Star

Timothy Omundson

Guest Star

Kim Rhodes

Charlie Bradbury

Felicia Day

Guest Star

Travis Aaron Wade

Guest Star

Kathryn Love Newton

Calliope

Hannah Levien

Guest Star

Britni Sheridan

Rowena MacLeod

Ruth Connell

Guest Star

Stephen Daniel Curtis

Guest Star

Mark Acheson

Hannah / Caroline Johnson / Young Mother

Erica Carroll

Guest Star

Jeff Branson

Guest Star

Lesley Nicol

Guest Star

Teryl Rothery

Bobby Singer

Jim Beaver

Guest Star

Leisha Hailey

Donna Hanscum

Briana Buckmaster

Guest Star

Curtis Armstrong

Jack / Belphegor

Alexander Calvert

Mary Winchester

Samantha Smith

Lucifer

Mark Pellegrino

Arthur Ketch

David Haydn-Jones

Amara / Amara (Adult) / Karin

Emily Swallow

Ruby / Genevieve Padalecki

Genevieve Padalecki

Gabriel / Trickster

Richard Speight Jr.

John Winchester

Jeffrey Dean Morgan

Lisa Braeden

Cindy Sampson

Billie

Lisa Berry

Eli / Benny Lafitte

Ty Olsson

Naomi

Amanda Tapping

Kelly Kline

Courtney Ford

Donatello Redfield / God

Keith Szarabajka

Adam Milligan / Michael

Jake Abel

Duma / The Shadow / Robin

Erica Cerra

Samuel Campbell / Shapeshifter

Mitch Pileggi

Zachariah

Kurt Fuller

Ellen Harvelle

Samantha Ferris

Kevin Tran

Osric Chau

Meg Masters

Rachel Miner

Abaddon

Alaina Huffman

Eileen Leahy

Shoshannah Stern

Maggie

Katherine Evans

Jo Harvelle

Alona Tal

Liane Balaban

Balthazar

Sebastian Roché

Young Sam Winchester

Colin Ford

Rufus Turner

Steven Williams

Garth Fitzgerald / Garth Fitzgerald

DJ Qualls

Toni Bevell

Elizabeth Blackmore

Anna Milton

Julie McNiven

Bela Talbot

Lauren Cohan

Ruby

Katie Cassidy

God

Rob Benedict

Jessica Moore

Adrianne Palicki

Death

Julian Richings

Edgar

Benito Martinez

Ben Braeden

Nicholas Elia

Gadreel / Ezekiel

Tahmoh Penikett

Meg Masters

Nicki Aycox

Mick Davies

Adam Fergus

Pamela Barnes

Traci Dinwiddie

Sister Jo / Anael

Danneel Ackles

Uriel

Robert Wisdom

Michael

Christian Keyes

Asmodeus

Jeffrey Vincent Parise

Alex Jones

Katherine Ramdeen

Kaia Nieves / Dark Kaia

Yadira Guevara-Prip

Ash

Chad Lindberg