Sam Winchester

Jared Padalecki

Dean Winchester

Jensen Ackles

Mary Winchester

Samantha Smith

Guest Star

C. Malik Whitfield

Guest Star

Katharine Isabelle

Guest Star

Annie Wersching

Guest Star

Tricia Helfer

Guest Star

Sterling K. Brown

John Winchester

Jeffrey Dean Morgan

Ellen Harvelle

Samantha Ferris

Guest Star

Gabriel Tigerman

Guest Star

Nate Quinlan

Guest Star

Linda Blair

Guest Star

Gary Cole

Bobby Singer

Jim Beaver

Guest Star

Aldis Hodge

Castiel / Emmanuel / Jimmy Novak

Misha Collins

Guest Star

Jason Gedrick

Jo Harvelle

Alona Tal

Jessica Moore

Adrianne Palicki

Guest Star

Matreya Fedor

Guest Star

Amber Benson

Guest Star

Emmanuelle Vaugier

Crowley

Mark Sheppard

Tessa/Reaper

Lindsey McKeon

Guest Star

Michelle Borth

Janitor

Frederic Land

Guest Star

Melanie Neige Scrofano

Truck Driver

Marcel Maillard

Rowena MacLeod

Ruth Connell

EMT

Sarah Groundwater

Jack / Belphegor

Alexander Calvert

Another EMT

Randal Edwards

Third EMT

Benson Simmonds

Lucifer

Mark Pellegrino

Attending Doctor

Julian D. Christopher

Arthur Ketch

David Haydn-Jones

Doctor No. 2

Todd Woffinden

Jody Mills

Kim Rhodes

Nurse No. 1

Marsha Regis

Amara / Amara (Adult) / Karin

Emily Swallow

Ruby / Genevieve Padalecki

Genevieve Padalecki

Nurse No. 2

Nicola Anderson

Wounded Man

Pete Antico

Metatron

Curtis Armstrong

Gabriel / Trickster

Richard Speight Jr.

Orderly

Daniel Bacon

Perky Woman

Sharon Bell

Charlie Bradbury

Felicia Day

Blonde Nurse

Carrie Anne Fleming

Lisa Braeden

Cindy Sampson

Billie

Lisa Berry

Eli / Benny Lafitte

Ty Olsson

Naomi

Amanda Tapping

Kelly Kline

Courtney Ford

Donatello Redfield / God

Keith Szarabajka

Adam Milligan / Michael

Jake Abel

Hannah / Caroline Johnson / Young Mother

Erica Carroll

Duma / The Shadow / Robin

Erica Cerra

Samuel Campbell / Shapeshifter

Mitch Pileggi

Zachariah

Kurt Fuller

Meg Masters

Rachel Miner

Abaddon

Alaina Huffman

Eileen Leahy

Shoshannah Stern

Maggie

Katherine Evans

Donna Hanscum

Briana Buckmaster

Kevin Tran

Osric Chau

Balthazar

Sebastian Roché

Claire Novak

Kathryn Newton

Young Sam Winchester

Colin Ford

Rufus Turner

Steven Williams

Garth Fitzgerald / Garth Fitzgerald

DJ Qualls

Toni Bevell

Elizabeth Blackmore

Anna Milton

Julie McNiven

Bela Talbot

Lauren Cohan

Ruby

Katie Cassidy

God

Rob Benedict

Death

Julian Richings

Edgar

Benito Martinez

Ben Braeden

Nicholas Elia

Gadreel / Ezekiel

Tahmoh Penikett

Meg Masters

Nicki Aycox

Mick Davies

Adam Fergus

Pamela Barnes

Traci Dinwiddie

Sister Jo / Anael

Danneel Ackles

Uriel

Robert Wisdom

Michael

Christian Keyes

Asmodeus

Jeffrey Vincent Parise

Alex Jones

Katherine Ramdeen

Kaia Nieves / Dark Kaia

Yadira Guevara-Prip

Ash

Chad Lindberg