Sam Winchester

Jared Padalecki

Dean Winchester

Jensen Ackles

Mary Winchester

Samantha Smith

Guest Star

C. Malik Whitfield

Guest Star

Katharine Isabelle

Guest Star

Annie Wersching

Guest Star

Tricia Helfer

Guest Star

Sterling K. Brown

John Winchester

Jeffrey Dean Morgan

Ellen Harvelle

Samantha Ferris

Guest Star

Gabriel Tigerman

Guest Star

Nate Quinlan

Guest Star

Linda Blair

Guest Star

Gary Cole

Bobby Singer

Jim Beaver

Guest Star

Aldis Hodge

Castiel / Emmanuel

Misha Collins

Guest Star

Jason Gedrick

Jo Harvelle

Alona Tal

Guest Star

Adrianne Palicki

Guest Star

Matreya Fedor

Guest Star

Amber Benson

Guest Star

Emmanuelle Vaugier

Crowley

Mark Sheppard

Tessa/Reaper

Lindsey McKeon

Guest Star

Michelle Borth

Janitor

Frederic Land

Guest Star

Melanie Neige Scrofano

Truck Driver

Marcel Maillard

Rowena MacLeod

Ruth Connell

EMT

Sarah Groundwater

Jody Mills

Kim Rhodes

Another EMT

Randal Edwards

Third EMT

Benson Simmonds

Amara / Amara (Adult) / Karin

Emily Swallow

Attending Doctor

Julian D. Christopher

Ruby / Genevieve Padalecki

Genevieve Padalecki

Doctor No. 2

Todd Woffinden

Gabriel / Trickster

Richard Speight Jr.

Charlie Bradbury

Felicia Day

Nurse No. 1

Marsha Regis

Nurse No. 2

Nicola Anderson

Wounded Man

Pete Antico

Lisa Braeden

Cindy Sampson

Orderly

Daniel Bacon

Billie

Lisa Berry

Perky Woman

Sharon Bell

Metatron

Curtis Armstrong

Eli / Benny Lafitte

Ty Olsson

Blonde Nurse

Carrie Anne Fleming

Kelly Kline

Courtney Ford

Donatello Redfield / God

Keith Szarabajka

Adam Milligan / Michael

Jake Abel

Hannah / Caroline Johnson / Young Mother

Erica Carroll

Samuel Campbell / Shapeshifter

Mitch Pileggi

Zachariah

Kurt Fuller

Meg Masters

Rachel Miner

Eileen Leahy

Shoshannah Stern

Maggie

Katherine Evans

Donna Hanscum

Briana Buckmaster

Balthazar

Sebastian Roché

Claire Novak

Kathryn Newton

Young Sam Winchester

Colin Ford

Rufus Turner

Steven Williams

Toni Bevell

Elizabeth Blackmore

Anna Milton

Julie McNiven

Bela Talbot

Lauren Cohan

Ruby

Katie Cassidy

God

Rob Benedict

Edgar

Benito Martinez

Ben Braeden

Nicholas Elia

Gadreel / Ezekiel

Tahmoh Penikett

Meg Masters

Nicki Aycox

Mick Davies

Adam Fergus

Pamela Barnes

Traci Dinwiddie

Sister Jo / Anael

Danneel Ackles

Uriel

Robert Wisdom

Michael

Christian Keyes

Asmodeus

Jeffrey Vincent Parise

Belphegor / Jack

Alexander Calvert

Alex Jones

Katherine Ramdeen

Ash

Chad Lindberg

Director

Jeannot Szwarc

Director

Guy Norman Bee

Director

Eduardo Sánchez

Director

Charles Beeson

Director

Richard Speight Jr.

Director

Jensen Ackles

Director

Rachel Talalay

Director

Steve Boyum

Director

Brad May

Director

P.J. Pesce

Director

James L. Conway

Director

J. Miller Tobin

Director

Mike Rohl

Director

Eric Kripke

Director

Robert Singer

Director

Kim Manners

Director

Tim Iacofano

Director

Amyn Kaderali

Director

Thomas J. Wright

Director

John Badham

Director

Nina Corrado