Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz

Nancy Cartwright

Lisa Marie Simpson

Yeardley Smith

Martin Prince (voice) / Sherri / Martin

Russi Taylor

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Milhouse (voice) / Milhouse / Jimbo (voice)

Pamela Hayden

Dolph

Tress MacNeille

Praline

Taraji P. Henson

Dumlee

Brian Posehn

Himself

Dan Fouts

Bostonian Doctor

Rachel Dratch

Virginia Johnson

Lizzy Caplan

Bourbon Verlander

Jason Alexander

Mona Simpson (voice)

Glenn Close

Edna Krabappel (voice) / Edna Krabappel / Ms. Melon (voice)

Marcia Wallace

Dr. Lionel Budgie (voice) / Mason Fairbanks (voice) / Nigel (voice)

Michael York

Mrs. Burns

Amy Schumer

Himself

Magnus Carlsen

Himself

Drew Carey

Julia

Allison Janney

Herself

Joyce Carol Oates

Himself

Dan Rather

Phoebe

Jennifer Saunders

Sophie

Natasha Lyonne

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard Duff (voice)

Stacy Keach

Himself

Stephen Curry

Isabella

Deb Lacusta

Himself

Mike Leinart

William Masters

Michael Sheen

Bart's Guilt

Patton Oswalt

Hyman Krustofsky (voice)

Jackie Mason

Jazzy James

Keegan-Michael Key

Dr. Fenton Pooltoy

Rob Riggle

Mr. Muntz/Narrator

Earl Mann

Himself

Donald Fagen

Himself

Neil deGrasse Tyson

Mrs. Butterworth

Valerie Harper

Boston Football Fan

Bill Burr

"Simpsons Time" Theme Song Singer

Pendleton Ward

Christoph Jablonka

Himself

Adam Silver

Rachel

Sarah Silverman

Himself

Ken Jennings

Fat Tony (voice) / Fit-Fat Tony (voice) / Gordus Antonius (voice)

Joe Mantegna

Rod Flanders (voice) / Helen Lovejoy (voice) / Luann Van Houten (voice)

Maggie Roswell

Security Guard / Burns' Cellmate / many minor characters

Kevin Michael Richardson

The Nerd

Seth Green

Murphy (voice) / Dana Gould (voice)

Dana Gould

Himself

Snoop Dogg

Himself

Wayne Gretzky

Himself

Theo Jansen

Himself

Robert McKee

"600" Singer

Judith Owen

Himself

RZA

(voice) / Boat Owner / Neighborhood Meeting Notification (voice)

Chris Edgerly

Anke Engelke

Lionel Hutz / Troy McClure / Lyle Lanley

Phil Hartman

Herself

Doris Kearns Goodwin

Sandra Schwittau

Herself

Suze Orman

Himself

Common

Boston Americans' Quarterback

Michael Chiklis

Sideshow Bob (voice)

Kelsey Grammer

Sabine Bohlmann

Army recruiter 2 / Billy / others characters (voice)

Maurice LaMarche

Himself

Charles Barkley

Himself

Stan Lee

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Artie Ziff / Llewellyn Sinclair / other minor characters.

Jon Lovitz

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

Bernice Hibbert (voice) / (voice) / Mrs. McBride (voice)

Dawnn Lewis

Jacques / Hank Scorpio / others characters (voice)

Albert Brooks

Constance Harm (voice) / Judge Harm (voice)

Jane Kaczmarek

Manjula (voice)

Jan Hooks

(voice) / Additional Voices (voice) / Bum #1

Karl Wiedergott*

Stephen Hawking (voice)

Stephen Hawking

Akira Kurosawa (voice)

George Takei

Victor Kleskow (voice)

J.K. Simmons

(voice) / Santa's Little Helper / various animals (voice)

Frank Welker

Girl (voice) / Weasel #2 / Richard

Jo Ann Harris

Director

Pete Michels

Director

Mike B. Anderson*

Director

Matthew Nastuk

Director

Neil Affleck

Director

Chuck Sheetz

Director

David Silverman

Director

Lauren MacMullan

Director

Dominic Polcino

Director

Swinton O. Scott III

Director

Rich Moore

Director

Raymond S. Persi

Director

Mark Kirkland

Director

Jennifer Moeller

Director

Mike B. Anderson

Director

Michael Polcino