Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie
Dan Castellaneta
Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier
Julie Kavner
Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz
Nancy Cartwright
Lisa Marie Simpson
Yeardley Smith
Martin Prince (voice) / Sherri / Martin
Russi Taylor
Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera
Hank Azaria
Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy
Harry Shearer
Milhouse (voice) / Milhouse / Jimbo (voice)
Pamela Hayden
Dolph
Tress MacNeille
Praline
Taraji P. Henson
Dumlee
Brian Posehn
Himself
Dan Fouts
Bostonian Doctor
Rachel Dratch
Virginia Johnson
Lizzy Caplan
Bourbon Verlander
Jason Alexander
Mona Simpson (voice)
Glenn Close
Edna Krabappel (voice) / Edna Krabappel / Ms. Melon (voice)
Marcia Wallace
Dr. Lionel Budgie (voice) / Mason Fairbanks (voice) / Nigel (voice)
Michael York
Mrs. Burns
Amy Schumer
Himself
Magnus Carlsen
Himself
Drew Carey
Julia
Allison Janney
Herself
Joyce Carol Oates
Himself
Dan Rather
Phoebe
Jennifer Saunders
Sophie
Natasha Lyonne
Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard Duff (voice)
Stacy Keach
Himself
Stephen Curry
Isabella
Deb Lacusta
Himself
Mike Leinart
William Masters
Michael Sheen
Bart's Guilt
Patton Oswalt
Hyman Krustofsky (voice)
Jackie Mason
Jazzy James
Keegan-Michael Key
Dr. Fenton Pooltoy
Rob Riggle
Mr. Muntz/Narrator
Earl Mann
Himself
Donald Fagen
Himself
Neil deGrasse Tyson
Mrs. Butterworth
Valerie Harper
Boston Football Fan
Bill Burr
"Simpsons Time" Theme Song Singer
Pendleton Ward
Christoph Jablonka
Himself
Adam Silver
Rachel
Sarah Silverman
Himself
Ken Jennings
Fat Tony (voice) / Fit-Fat Tony (voice) / Gordus Antonius (voice)
Joe Mantegna
Rod Flanders (voice) / Helen Lovejoy (voice) / Luann Van Houten (voice)
Maggie Roswell
Security Guard / Burns' Cellmate / many minor characters
Kevin Michael Richardson
The Nerd
Seth Green
Murphy (voice) / Dana Gould (voice)
Dana Gould
Himself
Snoop Dogg
Himself
Wayne Gretzky
Himself
Theo Jansen
Himself
Robert McKee
"600" Singer
Judith Owen
Himself
RZA
(voice) / Boat Owner / Neighborhood Meeting Notification (voice)
Chris Edgerly
Anke Engelke
Lionel Hutz / Troy McClure / Lyle Lanley
Phil Hartman
Herself
Doris Kearns Goodwin
Sandra Schwittau
Herself
Suze Orman
Himself
Common
Boston Americans' Quarterback
Michael Chiklis
Sideshow Bob (voice)
Kelsey Grammer
Sabine Bohlmann
Army recruiter 2 / Billy / others characters (voice)
Maurice LaMarche
Himself
Charles Barkley
Himself
Stan Lee
Carl Carlson (voice) / Lou (voice) / Carl Carlson
Alex Désert
Artie Ziff / Llewellyn Sinclair / other minor characters.
Jon Lovitz
Martin Prince (voice) / Sherri / Terri (voice)
Grey DeLisle
Bernice Hibbert (voice) / (voice) / Mrs. McBride (voice)
Dawnn Lewis
Jacques / Hank Scorpio / others characters (voice)
Albert Brooks
Constance Harm (voice) / Judge Harm (voice)
Jane Kaczmarek
Manjula (voice)
Jan Hooks
(voice) / Additional Voices (voice) / Bum #1
Karl Wiedergott*
Stephen Hawking (voice)
Stephen Hawking
Akira Kurosawa (voice)
George Takei
Victor Kleskow (voice)
J.K. Simmons
(voice) / Santa's Little Helper / various animals (voice)
Frank Welker
Girl (voice) / Weasel #2 / Richard
Jo Ann Harris
Director
Pete Michels
Director
Mike B. Anderson*
Director
Matthew Nastuk
Director
Neil Affleck
Director
Chuck Sheetz
Director
David Silverman
Director
Lauren MacMullan
Director
Dominic Polcino
Director
Swinton O. Scott III
Director
Rich Moore
Director
Raymond S. Persi
Director
Mark Kirkland
Director
Jennifer Moeller
Director
Mike B. Anderson
Director
Michael Polcino