Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz

Nancy Cartwright

Lisa Simpson (voice)

Yeardley Smith

Martin Prince (voice) / Martin Prince / Sherri

Russi Taylor

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Milhouse Van Houten (voice) / Milhouse (voice) / Milhouse Van Houten

Pamela Hayden

Dolph

Tress MacNeille

Praline

Taraji P. Henson

Dumlee

Brian Posehn

Himself

Dan Fouts

Bostonian Doctor

Rachel Dratch

Virginia Johnson

Lizzy Caplan

Bourbon Verlander

Jason Alexander

Mona Simpson (voice)

Glenn Close

Dr. Lionel Budgie (voice) / Nigel (voice) / Mason Fairbanks (voice)

Michael York

Mrs. Burns

Amy Schumer

Himself

Magnus Carlsen

Himself

Drew Carey

Julia

Allison Janney

Herself

Joyce Carol Oates

Himself

Dan Rather

Phoebe

Jennifer Saunders

Sophie

Natasha Lyonne

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard K. Duff VIII

Stacy Keach

Himself

Stephen Curry

Isabella

Deb Lacusta

Himself

Mike Leinart

William Masters

Michael Sheen

Bart's Guilt

Patton Oswalt

Hyman Krustofsky (voice)

Jackie Mason

Jazzy James

Keegan-Michael Key

Dr. Fenton Pooltoy

Rob Riggle

Edna Krabappel (voice) / Crowd (voice) / Edna Krabappel

Marcia Wallace

Mr. Muntz/Narrator

Earl Mann

Himself

Donald Fagen

Himself

Neil deGrasse Tyson

Mrs. Butterworth (voice) / Nurse (voice) / Ms. Myles (voice)

Valerie Harper

Boston Football Fan

Bill Burr

"Simpsons Time" Theme Song Singer

Pendleton Ward

Christoph Jablonka

Himself

Adam Silver

Rachel

Sarah Silverman

Himself

Ken Jennings

Fat Tony (voice) / Fat Tony / Fat Tony's Former Father (voice)

Joe Mantegna

Maude Flanders (voice) / Luann Van Houten (voice) / Helen Lovejoy (voice)

Maggie Roswell

Dr. Hibbert (voice) / (voice) / Narrator (voice)

Kevin Michael Richardson

The Nerd

Seth Green

Murphy (voice) / I.N.S. Agent (voice) / Dana Gould (voice)

Dana Gould

Himself

Snoop Dogg

Himself

Wayne Gretzky

Himself

Theo Jansen

Himself

Robert McKee

"600" Singer

Judith Owen

Himself

RZA

(voice) / Additional Voices (voice) / Laughing Crowd (voice)

Chris Edgerly

Anke Engelke

Herself

Doris Kearns Goodwin

Additional Voices (voice) / (voice) / Zombie Nurse

Karl Wiedergott*

Herself

Suze Orman

Himself

Common

Boston Americans' Quarterback

Michael Chiklis

Sandra Schwittau

Sideshow Bob (voice)

Kelsey Grammer

Orson Welles (voice) / (voice) / City Inspector (voice)

Maurice LaMarche

Himself

Charles Barkley

Himself

Stan Lee

Sabine Bohlmann

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

Troy McClure (voice) / Lionel Hutz (voice) / Lionel Hutz

Phil Hartman

Bernice Hibbert (voice) / (voice) / Court Bailiff (voice)

Dawnn Lewis

Artie Ziff (voice) / Llewellyn Sinclair (voice) / Enrico Irritazio (voice)

Jon Lovitz

Kumiko Albertson (voice) / Truth-Anne (voice) / (voice)

Jenny Yokobori

Lewis Clark (voice) / Janey Powell (voice) / Janine Powell (voice)

Kimberly Brooks

Julio Franco (voice) / Julio (voice) / (voice)

Tony Rodriguez

Jacques (voice) / Hank Scorpio (voice) / Slick Manager (voice)

Albert Brooks

Maude Flanders (voice) / Helen Lovejoy (voice) / Miss Hoover (voice)

Marcia Mitzman Gaven

Constance Harm (voice) / Judge Harm (voice) / Judge Constance Harm (voice)

Jane Kaczmarek

Rayshelle Peyton (voice)

Kerry Washington

Milhouse Van Houten (voice)

Kelly Macleod

Lunchlady Doris (voice) / Ice cream lady (voice) / Shotgun Pete's Receptionist (voice)

Doris Grau

Weasel (voice) / Martin Prince / Photography Club Member #3

Jo Ann Harris

Manjula Nahasapeemapetilon (voice)

Jan Hooks

Bumblebee Man (voice) / (voice) / Gambling Old Man (voice)

Eric Lopez

Baboons (voice) / Santa's Little Helper / Mr. Teeny

Frank Welker

Sarah Wiggum (voice)

Megan Mullally

Stephen Hawking (voice)

Stephen Hawking

Akira Kurosawa (voice) / George Takei (voice) / Wink - The Game Show Host (voice)

George Takei

Victor Kleskow (voice) / Dr. Jessup (voice) / JJ Gruff (voice)

J.K. Simmons

Axel (voice) / Bull (voice) / Balfalmagog (voice)

Jonathan Lipow