Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz

Nancy Cartwright

Alf Clausen

Lisa Simpson (voice)

Yeardley Smith

Daniel Chun*

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

John Frink

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Alan Decker

Tom O'Flanagan

Colm Meany

Milhouse Van Houten

Pamela Hayden

Himself

Joe Montana

Jenny

Anne Hathaway

Alaska Nebraska

Ellen Page

Mina

Shohreh Aghdashloo

Himself

Mark Cuban

Juliet Hobbes

Emily Blunt

Maggie Roark

Jodie Foster

Lucky Jim

Robert Foster

Himself

Will Shortz

HImself

Ed Begley Jr.

Sideshow Bob (voice)

Kelsey Grammer

Himself

Denis Leary

Tom Gammill

Irish Guy

Glen Hansard

Dolph

Tress MacNeille

Himself

Marv Albert

Himself

Brian Grazer

Fat Tony (voice) / Fit-Fat Tony (voice) / Gordus Antonius (voice)

Joe Mantegna

Themselves

Fall Out Boy

Himself

Merl Reagle

Dan Greaney

Gloria

Julia Louis-Dreyfus

Edna Krabappel (voice) / Edna Krabappel / Ms. Melon (voice)

Marcia Wallace

Irish Girl

Marketa Irglova

Himself

Jeff Bezos

Grady

Scott Thompson

Norbert Gastell

Army recruiter 2 / Billy / others characters (voice)

Maurice LaMarche

Rod Flanders (voice) / Helen Lovejoy (voice) / Luann Van Houten (voice)

Maggie Roswell

Anke Engelke

Sandra Schwittau

Martin Prince (voice) / Sherri / Martin

Russi Taylor

Lionel Hutz / Troy McClure / Lyle Lanley

Phil Hartman

(voice) / Additional Voices (voice) / Bum #1

Karl Wiedergott*

Security Guard / Burns' Cellmate / many minor characters

Kevin Michael Richardson

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Artie Ziff / Llewellyn Sinclair / other minor characters.

Jon Lovitz

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

(voice) / Boat Owner / Neighborhood Meeting Notification (voice)

Chris Edgerly

Bernice Hibbert (voice) / (voice) / Mrs. McBride (voice)

Dawnn Lewis

Mona Simpson (voice)

Glenn Close

Hyman Krustofsky (voice)

Jackie Mason

Jacques / Hank Scorpio / others characters (voice)

Albert Brooks

Constance Harm (voice) / Judge Harm (voice)

Jane Kaczmarek

Manjula (voice)

Jan Hooks

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard Duff (voice)

Stacy Keach

Murphy (voice) / Dana Gould (voice)

Dana Gould

Dr. Lionel Budgie (voice) / Mason Fairbanks (voice) / Nigel (voice)

Michael York

Stephen Hawking (voice)

Stephen Hawking

Akira Kurosawa (voice)

George Takei

Victor Kleskow (voice)

J.K. Simmons

(voice) / Santa's Little Helper / various animals (voice)

Frank Welker

Girl (voice) / Weasel #2 / Richard

Jo Ann Harris

Director

Pete Michels

Director

Neil Affleck

Director

Chuck Sheetz

Director

David Silverman

Director

Lauren MacMullan

Director

Dominic Polcino

Director

Swinton O. Scott III

Director

Rich Moore

Director

Matt Groening

Director

Raymond S. Persi

Director

Mark Kirkland

Director

Jennifer Moeller

Director

Mike B. Anderson

Director

Michael Polcino