Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie
Dan Castellaneta
Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier
Julie Kavner
Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz
Nancy Cartwright
Alf Clausen
Lisa Simpson (voice)
Yeardley Smith
Daniel Chun*
Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera
Hank Azaria
John Frink
Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy
Harry Shearer
Alan Decker
Tom O'Flanagan
Colm Meany
Milhouse Van Houten
Pamela Hayden
Himself
Joe Montana
Jenny
Anne Hathaway
Alaska Nebraska
Ellen Page
Mina
Shohreh Aghdashloo
Himself
Mark Cuban
Juliet Hobbes
Emily Blunt
Maggie Roark
Jodie Foster
Lucky Jim
Robert Foster
Himself
Will Shortz
HImself
Ed Begley Jr.
Sideshow Bob (voice)
Kelsey Grammer
Himself
Denis Leary
Tom Gammill
Irish Guy
Glen Hansard
Dolph
Tress MacNeille
Himself
Marv Albert
Himself
Brian Grazer
Fat Tony (voice) / Fit-Fat Tony (voice) / Gordus Antonius (voice)
Joe Mantegna
Themselves
Fall Out Boy
Himself
Merl Reagle
Dan Greaney
Gloria
Julia Louis-Dreyfus
Edna Krabappel (voice) / Edna Krabappel / Ms. Melon (voice)
Marcia Wallace
Irish Girl
Marketa Irglova
Himself
Jeff Bezos
Grady
Scott Thompson
Norbert Gastell
Army recruiter 2 / Billy / others characters (voice)
Maurice LaMarche
Rod Flanders (voice) / Helen Lovejoy (voice) / Luann Van Houten (voice)
Maggie Roswell
Anke Engelke
Sandra Schwittau
Martin Prince (voice) / Sherri / Martin
Russi Taylor
Lionel Hutz / Troy McClure / Lyle Lanley
Phil Hartman
(voice) / Additional Voices (voice) / Bum #1
Karl Wiedergott*
Security Guard / Burns' Cellmate / many minor characters
Kevin Michael Richardson
Carl Carlson (voice) / Lou (voice) / Carl Carlson
Alex Désert
Artie Ziff / Llewellyn Sinclair / other minor characters.
Jon Lovitz
Martin Prince (voice) / Sherri / Terri (voice)
Grey DeLisle
(voice) / Boat Owner / Neighborhood Meeting Notification (voice)
Chris Edgerly
Bernice Hibbert (voice) / (voice) / Mrs. McBride (voice)
Dawnn Lewis
Mona Simpson (voice)
Glenn Close
Hyman Krustofsky (voice)
Jackie Mason
Jacques / Hank Scorpio / others characters (voice)
Albert Brooks
Constance Harm (voice) / Judge Harm (voice)
Jane Kaczmarek
Manjula (voice)
Jan Hooks
Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard Duff (voice)
Stacy Keach
Murphy (voice) / Dana Gould (voice)
Dana Gould
Dr. Lionel Budgie (voice) / Mason Fairbanks (voice) / Nigel (voice)
Michael York
Stephen Hawking (voice)
Stephen Hawking
Akira Kurosawa (voice)
George Takei
Victor Kleskow (voice)
J.K. Simmons
(voice) / Santa's Little Helper / various animals (voice)
Frank Welker
Girl (voice) / Weasel #2 / Richard
Jo Ann Harris
Director
Pete Michels
Director
Neil Affleck
Director
Chuck Sheetz
Director
David Silverman
Director
Lauren MacMullan
Director
Dominic Polcino
Director
Swinton O. Scott III
Director
Rich Moore
Director
Matt Groening
Director
Raymond S. Persi
Director
Mark Kirkland
Director
Jennifer Moeller
Director
Mike B. Anderson
Director
Michael Polcino