Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Bart Simpson/Nelson Muntz/Todd Flanders/Ralph Wiggum/Kearney

Nancy Cartwright

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Lisa Simpson (voice)

Yeardley Smith

Edna Krabappel (voice) / Edna Krabappel / Ms. Melon (voice)

Marcia Wallace

Ms. Dare / Gwen / Homer's Cousin's Wife (voice)

Tress MacNeille

Himself

Jay Leno

Guest Voice

U2

Himself

Fyvush Finkel

Sgt. Seymour Skinner

Martin Sheen

Captain Tenille

Rod Steiger

Himself

Alex Trebek

Renee

Helen Hunt

Cooder

Jim Varney

Himself

Stephen Jay Gould

Rod Flanders (voice) / Helen Lovejoy (voice) / Luann Van Houten (voice)

Maggie Roswell

Himself

George Harrison

Brad

Brendan Fraser

Lionel Hutz / Troy McClure / Lyle Lanley

Phil Hartman

Himself

Joe Namath

Voice

Mike Judge

Manjula Nahasapeemapetilon

Jan Hooks

Narrator

James Earl Jones

Milhouse (voice) / Milhouse / Jimbo (voice)

Pamela Hayden

Neil

Steven Weber

Himself

Bob Denver

Herself

Janeane Garofalo

Apu's Mother

Andrea Martin

Ray Patterson

Steve Martin

Woman on Phone

Joan Kenley

Drill Sergeant

Michael Carrington

Himself

Bobcat Goldthwait

New York, New York Singer

Michael Dees

Martin Prince (voice) / Sherri / Martin

Russi Taylor

Himself

Bruce Baum

Lunchlady Doris

Doris Grau

Village People

Randy Jones

Norbert Gastell

Fat Tony (voice) / Fit-Fat Tony (voice) / Gordus Antonius (voice)

Joe Mantegna

Lucious Sweet

Paul Winfield

'Canyonero' Singer

Hank Williams Jr.

Red Head Female Cartoon Character Model

Monique Yates Jr.

Chinese Fisherman

Jack Ong

Bubble Gump

Riley Brock

Sandra Schwittau

Herself

Susie Smith

Himself

Roy Firestone

Himself

Paul McGuinness

Security Guard / Burns' Cellmate / many minor characters

Kevin Michael Richardson

Sideshow Bob (voice)

Kelsey Grammer

Army recruiter 2 / Billy / others characters (voice)

Maurice LaMarche

(voice) / Additional Voices (voice) / Bum #1

Karl Wiedergott*

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Artie Ziff / Llewellyn Sinclair / other minor characters.

Jon Lovitz

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

(voice) / Boat Owner / Neighborhood Meeting Notification (voice)

Chris Edgerly

Bernice Hibbert (voice) / (voice) / Mrs. McBride (voice)

Dawnn Lewis

Mona Simpson (voice)

Glenn Close

Hyman Krustofsky (voice)

Jackie Mason

Jacques / Hank Scorpio / others characters (voice)

Albert Brooks

Constance Harm (voice) / Judge Harm (voice)

Jane Kaczmarek

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard Duff (voice)

Stacy Keach

Murphy (voice) / Dana Gould (voice)

Dana Gould

Dr. Lionel Budgie (voice) / Mason Fairbanks (voice) / Nigel (voice)

Michael York

Stephen Hawking (voice)

Stephen Hawking

Akira Kurosawa (voice)

George Takei

Victor Kleskow (voice)

J.K. Simmons

(voice) / Santa's Little Helper / various animals (voice)

Frank Welker

Girl (voice) / Weasel #2 / Richard

Jo Ann Harris

Director

Pete Michels

Director

Steven Dean Moore

Director

Neil Affleck

Director

Chuck Sheetz

Director

David Silverman

Director

Lauren MacMullan

Director

Dominic Polcino

Director

Swinton O. Scott III

Director

Rich Moore

Director

Raymond S. Persi

Director

Mark Kirkland

Director

Jennifer Moeller

Director

Mike B. Anderson

Director

Michael Polcino