Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Lisa Simpson (voice)

Yeardley Smith

Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz

Nancy Cartwright

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Bleeding Gums Murphy

Ron Taylor

Hugh St. John Alastair Parkfield

Mandy Patinkin

Guest Voice

Milton Berle

Ballet Teacher

Susan Sarandon

(voice) / Santa's Little Helper / various animals (voice)

Frank Welker

Himself

Dennis Franz

Ms. Dare / Gwen / Homer's Cousin's Wife (voice)

Tress MacNeille

Milhouse (voice) / Milhouse / Jimbo (voice)

Pamela Hayden

Jacques / Hank Scorpio / others characters (voice)

Albert Brooks

Artie Ziff / Llewellyn Sinclair / other minor characters.

Jon Lovitz

Edna Krabappel (voice) / Edna Krabappel / Ms. Melon (voice)

Marcia Wallace

Jessica Lovejoy

Meryl Streep

Number One

Patrick Stewart

Allison Taylor

Winona Ryder

Sideshow Bob (voice)

Kelsey Grammer

Himself

Dick Cavett

Maggie Simpson

James Earl Jones

Dr. Zweig

Anne Bancroft

Himself

Mel Brooks

Fat Tony (voice) / Fit-Fat Tony (voice) / Gordus Antonius (voice)

Joe Mantegna

Guest Voice

Kareem Abdul-Jabbar

Lunchlady Doris

Doris Grau

Rod Flanders (voice) / Helen Lovejoy (voice) / Luann Van Houten (voice)

Maggie Roswell

Dr. Demento

Barry Hansen

Himself

Steve Allen

Sam Malone

Ted Danson

Laura Powers

Sara Gilbert

Lionel Hutz / Troy McClure / Lyle Lanley

Phil Hartman

Carla Tortelli

Rhea Perlman

Himself

Johnny Unitas

Army recruiter 2 / Billy / others characters (voice)

Maurice LaMarche

Martin Prince (voice) / Sherri / Martin

Russi Taylor

Himsef

Tito Puente

Norm Peterson

George Wendt

Himself

Larry King

(voice) / Additional Voices (voice) / Bum #1

Karl Wiedergott*

Woody Boyd

Woody Harrelson

Norbert Gastell

Mindy Simmons

Michelle Pfeiffer

Cliff Clavin

John Ratzenberger

Fred Flintstone

Henry Corden

Elisabeth Volkmann

Sandra Schwittau

Krusty the Clown Show Announcer

Michael Carrington

Security Guard / Burns' Cellmate / many minor characters

Kevin Michael Richardson

Sabine Bohlmann

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

(voice) / Boat Owner / Neighborhood Meeting Notification (voice)

Chris Edgerly

Bernice Hibbert (voice) / (voice) / Mrs. McBride (voice)

Dawnn Lewis

Mona Simpson (voice)

Glenn Close

Hyman Krustofsky (voice)

Jackie Mason

Constance Harm (voice) / Judge Harm (voice)

Jane Kaczmarek

Manjula (voice)

Jan Hooks

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard Duff (voice)

Stacy Keach

Murphy (voice) / Dana Gould (voice)

Dana Gould

Dr. Lionel Budgie (voice) / Mason Fairbanks (voice) / Nigel (voice)

Michael York

Stephen Hawking (voice)

Stephen Hawking

Akira Kurosawa (voice)

George Takei

Victor Kleskow (voice)

J.K. Simmons

Girl (voice) / Weasel #2 / Richard

Jo Ann Harris

Director

Pete Michels

Director

Neil Affleck

Director

Chuck Sheetz

Director

David Silverman

Director

Lauren MacMullan

Director

Dominic Polcino

Director

Swinton O. Scott III

Director

Rich Moore

Director

Raymond S. Persi

Director

Mark Kirkland

Director

Jennifer Moeller

Director

Mike B. Anderson

Director

Michael Polcino