Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz

Nancy Cartwright

Lisa Marie Simpson

Yeardley Smith

Martin Prince (voice) / Sherri / Martin

Russi Taylor

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Milhouse (voice) / Milhouse / Jimbo (voice)

Pamela Hayden

Ms. Dare / Gwen / Homer's Cousin's Wife (voice)

Tress MacNeille

Walter Hottenhoffer

Werner Herzog

Self

Jason Momoa

Herself

Dr. Jane Goodall

Self

Jim Parsons

Mona Simpson (voice)

Glenn Close

Chinnos

Kevin Feige

Self

Kevin Smith

Edna Krabappel (voice) / Edna Krabappel / Ms. Melon (voice)

Marcia Wallace

Mike Wegman

Michael Rapaport

Self

John Legend

Bode

Pete Holmes

Evelyn

Fortune Feimster

Warburton Parker

John Mulaney

Bella-Ella

Lili Reinhart

Elaine

Cate Blanchett

Himself

Scott Bakula

Paula

Asia Kate Dillon

Mob Lawyer

Bob Odenkirk

Himself

Dr. Drew Pinsky

Desmond

Billy Porter

Hydrangea

Cobie Smulders

Self

Ed "Too Tall" Jones

Addy

Joey King

Self

Chrissy Teigen

Himself

Steve Ballmer

Sloan

Madelaine Petsch

Rod Flanders (voice) / Helen Lovejoy (voice) / Luann Van Houten (voice)

Maggie Roswell

(voice) / Boat Owner / Neighborhood Meeting Notification (voice)

Chris Edgerly

Zane

Zach Woods

Lauren

Chelsea Peretti

Movie Executive

Joseph Russo

Movie Executive

Anthony Russo

Security Guard / Burns' Cellmate / many minor characters

Kevin Michael Richardson

Lionel Hutz / Troy McClure / Lyle Lanley

Phil Hartman

Kensey

Lilly Singh

Glen Tangier/Airshot

Taran Killam

Fat Tony (voice) / Fit-Fat Tony (voice) / Gordus Antonius (voice)

Joe Mantegna

Tessa Rose

Camila Mendes

Reaction Guy

Tal Fishman

Guest Voice

Weezer

Sideshow Bob (voice)

Kelsey Grammer

Army recruiter 2 / Billy / others characters (voice)

Maurice LaMarche

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Artie Ziff / Llewellyn Sinclair / other minor characters.

Jon Lovitz

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

Bernice Hibbert (voice) / (voice) / Mrs. McBride (voice)

Dawnn Lewis

Hyman Krustofsky (voice)

Jackie Mason

Jacques / Hank Scorpio / others characters (voice)

Albert Brooks

Constance Harm (voice) / Judge Harm (voice)

Jane Kaczmarek

Manjula (voice)

Jan Hooks

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard Duff (voice)

Stacy Keach

Murphy (voice) / Dana Gould (voice)

Dana Gould

(voice) / Additional Voices (voice) / Bum #1

Karl Wiedergott*

Dr. Lionel Budgie (voice) / Mason Fairbanks (voice) / Nigel (voice)

Michael York

Stephen Hawking (voice)

Stephen Hawking

Akira Kurosawa (voice)

George Takei

Victor Kleskow (voice)

J.K. Simmons

(voice) / Santa's Little Helper / various animals (voice)

Frank Welker

Girl (voice) / Weasel #2 / Richard

Jo Ann Harris

Director

Pete Michels

Director

Mike B. Anderson*

Director

Steven Dean Moore

Director

Matthew Nastuk

Director

Neil Affleck

Director

Chuck Sheetz

Director

David Silverman

Director

Lauren MacMullan

Director

Dominic Polcino

Director

Swinton O. Scott III

Director

Rich Moore

Director

Raymond S. Persi

Director

Mark Kirkland

Director

Jennifer Moeller

Director

Mike B. Anderson

Director

Michael Polcino