Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz

Nancy Cartwright

Lisa Marie Simpson

Yeardley Smith

Martin Prince (voice) / Martin Prince / Sherri

Russi Taylor

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Milhouse Van Houten (voice) / Milhouse (voice) / Milhouse Van Houten

Pamela Hayden

Dolph

Tress MacNeille

Walter Hottenhoffer

Werner Herzog

Self

Jason Momoa

Herself

Dr. Jane Goodall

Self

Jim Parsons

Mona Simpson (voice)

Glenn Close

Chinnos

Kevin Feige

Self

Kevin Smith

Mike Wegman

Michael Rapaport

Self

John Legend

Bode

Pete Holmes

Evelyn

Fortune Feimster

Warburton Parker

John Mulaney

Bella-Ella

Lili Reinhart

Elaine

Cate Blanchett

Himself

Scott Bakula

Paula

Asia Kate Dillon

Mob Lawyer

Bob Odenkirk

Himself

Dr. Drew Pinsky

Desmond

Billy Porter

Hydrangea

Cobie Smulders

Self

Ed "Too Tall" Jones

Edna Krabappel (voice) / Crowd (voice) / Edna Krabappel

Marcia Wallace

Addy

Joey King

Self

Chrissy Teigen

Himself

Steve Ballmer

Sloan

Madelaine Petsch

Maude Flanders (voice) / Luann Van Houten (voice) / Helen Lovejoy (voice)

Maggie Roswell

(voice) / Additional Voices (voice) / Laughing Crowd (voice)

Chris Edgerly

Zane

Zach Woods

Lauren

Chelsea Peretti

Movie Executive

Joseph Russo

Movie Executive

Anthony Russo

Dr. Hibbert (voice) / (voice) / Narrator (voice)

Kevin Michael Richardson

Kensey

Lilly Singh

Additional Voices (voice) / (voice) / Zombie Nurse

Karl Wiedergott

Glen Tangier/Airshot

Taran Killam

Tessa Rose

Camila Mendes

Reaction Guy

Tal Fishman

Guest Voice

Weezer

Sideshow Bob (voice)

Kelsey Grammer

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

Fat Tony (voice) / Fat Tony / Fat Tony's Former Father (voice)

Joe Mantegna

Troy McClure (voice) / Lionel Hutz (voice) / Lionel Hutz

Phil Hartman

Bernice Hibbert (voice) / (voice) / Court Bailiff (voice)

Dawnn Lewis

Orson Welles (voice) / (voice) / City Inspector (voice)

Maurice LaMarche

Artie Ziff (voice) / Llewellyn Sinclair (voice) / Enrico Irritazio (voice)

Jon Lovitz

Kumiko Albertson (voice) / Truth-Anne (voice) / (voice)

Jenny Yokobori

Lewis Clark (voice) / Janey Powell (voice) / Janine Powell (voice)

Kimberly Brooks

Julio Franco (voice) / Julio (voice) / (voice)

Tony Rodriguez

Hyman Krustofsky (voice)

Jackie Mason

Jacques (voice) / Hank Scorpio (voice) / Slick Manager (voice)

Albert Brooks

Maude Flanders (voice) / Helen Lovejoy (voice) / Miss Hoover (voice)

Marcia Mitzman Gaven

Constance Harm (voice) / Judge Harm (voice) / Judge Constance Harm (voice)

Jane Kaczmarek

Rayshelle Peyton (voice)

Kerry Washington

Milhouse Van Houten (voice)

Kelly Macleod

Lunchlady Doris (voice) / Ice cream lady (voice) / Shotgun Pete's Receptionist (voice)

Doris Grau

Weasel (voice) / Martin Prince / Photography Club Member #3

Jo Ann Harris

Manjula Nahasapeemapetilon (voice)

Jan Hooks

Mrs. Butterworth (voice) / Nurse (voice) / Ms. Myles (voice)

Valerie Harper

Bumblebee Man (voice) / (voice) / Gambling Old Man (voice)

Eric Lopez

Baboons (voice) / Santa's Little Helper / Mr. Teeny

Frank Welker

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard K. Duff VIII

Stacy Keach

Murphy (voice) / I.N.S. Agent (voice) / Dana Gould (voice)

Dana Gould

Dr. Lionel Budgie (voice) / Nigel (voice) / Mason Fairbanks (voice)

Michael York

Sarah Wiggum (voice)

Megan Mullally

Stephen Hawking (voice)

Stephen Hawking

Akira Kurosawa (voice) / George Takei (voice) / Wink - The Game Show Host (voice)

George Takei

Victor Kleskow (voice) / Dr. Jessup (voice) / JJ Gruff (voice)

J.K. Simmons

Axel (voice) / Bull (voice) / Balfalmagog (voice)

Jonathan Lipow