Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie
Dan Castellaneta
Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier
Julie Kavner
Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz
Nancy Cartwright
Lisa Marie Simpson
Yeardley Smith
Martin Prince (voice) / Sherri / Martin
Russi Taylor
Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera
Hank Azaria
Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy
Harry Shearer
Milhouse (voice) / Milhouse / Jimbo (voice)
Pamela Hayden
Ms. Dare / Gwen / Homer's Cousin's Wife (voice)
Tress MacNeille
Walter Hottenhoffer
Werner Herzog
Self
Jason Momoa
Herself
Dr. Jane Goodall
Self
Jim Parsons
Mona Simpson (voice)
Glenn Close
Chinnos
Kevin Feige
Self
Kevin Smith
Edna Krabappel (voice) / Edna Krabappel / Ms. Melon (voice)
Marcia Wallace
Mike Wegman
Michael Rapaport
Self
John Legend
Bode
Pete Holmes
Evelyn
Fortune Feimster
Warburton Parker
John Mulaney
Bella-Ella
Lili Reinhart
Elaine
Cate Blanchett
Himself
Scott Bakula
Paula
Asia Kate Dillon
Mob Lawyer
Bob Odenkirk
Himself
Dr. Drew Pinsky
Desmond
Billy Porter
Hydrangea
Cobie Smulders
Self
Ed "Too Tall" Jones
Addy
Joey King
Self
Chrissy Teigen
Himself
Steve Ballmer
Sloan
Madelaine Petsch
Rod Flanders (voice) / Helen Lovejoy (voice) / Luann Van Houten (voice)
Maggie Roswell
(voice) / Boat Owner / Neighborhood Meeting Notification (voice)
Chris Edgerly
Zane
Zach Woods
Lauren
Chelsea Peretti
Movie Executive
Joseph Russo
Movie Executive
Anthony Russo
Security Guard / Burns' Cellmate / many minor characters
Kevin Michael Richardson
Lionel Hutz / Troy McClure / Lyle Lanley
Phil Hartman
Kensey
Lilly Singh
Glen Tangier/Airshot
Taran Killam
Fat Tony (voice) / Fit-Fat Tony (voice) / Gordus Antonius (voice)
Joe Mantegna
Tessa Rose
Camila Mendes
Reaction Guy
Tal Fishman
Guest Voice
Weezer
Sideshow Bob (voice)
Kelsey Grammer
Army recruiter 2 / Billy / others characters (voice)
Maurice LaMarche
Carl Carlson (voice) / Lou (voice) / Carl Carlson
Alex Désert
Artie Ziff / Llewellyn Sinclair / other minor characters.
Jon Lovitz
Martin Prince (voice) / Sherri / Terri (voice)
Grey DeLisle
Bernice Hibbert (voice) / (voice) / Mrs. McBride (voice)
Dawnn Lewis
Hyman Krustofsky (voice)
Jackie Mason
Jacques / Hank Scorpio / others characters (voice)
Albert Brooks
Constance Harm (voice) / Judge Harm (voice)
Jane Kaczmarek
Manjula (voice)
Jan Hooks
Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard Duff (voice)
Stacy Keach
Murphy (voice) / Dana Gould (voice)
Dana Gould
(voice) / Additional Voices (voice) / Bum #1
Karl Wiedergott*
Dr. Lionel Budgie (voice) / Mason Fairbanks (voice) / Nigel (voice)
Michael York
Stephen Hawking (voice)
Stephen Hawking
Akira Kurosawa (voice)
George Takei
Victor Kleskow (voice)
J.K. Simmons
(voice) / Santa's Little Helper / various animals (voice)
Frank Welker
Girl (voice) / Weasel #2 / Richard
Jo Ann Harris
Director
Pete Michels
Director
Mike B. Anderson*
Director
Steven Dean Moore
Director
Matthew Nastuk
Director
Neil Affleck
Director
Chuck Sheetz
Director
David Silverman
Director
Lauren MacMullan
Director
Dominic Polcino
Director
Swinton O. Scott III
Director
Rich Moore
Director
Raymond S. Persi
Director
Mark Kirkland
Director
Jennifer Moeller
Director
Mike B. Anderson
Director
Michael Polcino