Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Lisa Simpson (voice)

Yeardley Smith

Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz

Nancy Cartwright

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Himself

Paul McCartney

Erin

Christina Ricci

Himself

Peter Frampton

Agnes Skinner (voice) / (voice) / Dolph (voice)

Tress MacNeille

Hollis Hurlbut

Donald Sutherland

Fat Tony (voice) / Fat Tony / Fat Tony's Former Father (voice)

Joe Mantegna

Mona Simpson (voice)

Glenn Close

Chester J. Lampwick

Kirk Douglas

Don Brodka

Lawrence Tierney

Himself

Tom Kite

Himself

Paul Anka

Sideshow Bob (voice)

Kelsey Grammer

himself

Tito Puente

Himself

Bob Newhart

Woman on Phone

Joan Kenley

Bill Gannon

Harry Morgan

Herself

Kim Gordon

Himself

Mickey Rooney

Herself

Suzanne Somers

Milhouse Van Houten (voice) / Milhouse (voice) / Milhouse Van Houten

Pamela Hayden

himself

Buzz Aldrin

Herself

Linda McCartney

Guest Voice

Daryl Gates

MacArthur Parker

Jeff Goldblum

Colonel Leslie Hapablap

R. Lee Ermey

Troy McClure (voice) / Lionel Hutz (voice) / Lionel Hutz

Phil Hartman

Roger Meyers Jr.

Alex Rocco

Himself

B-Real

Edna Krabappel (voice) / Crowd (voice) / Edna Krabappel

Marcia Wallace

Lead Vocalist

George Balmaseda

Hong Kong Doctor

Jim Lau

Lunchlady Doris (voice) / Ice cream lady (voice) / Shotgun Pete's Receptionist (voice)

Doris Grau

Himself

DJ Muggs

Maude Flanders (voice) / Luann Van Houten (voice) / Helen Lovejoy (voice)

Maggie Roswell

Martin Prince (voice) / Martin Prince / Sherri

Russi Taylor

Himself

Sen Dog

Baboons (voice) / Santa's Little Helper / Mr. Teeny

Frank Welker

The Amendment

Jack Sheldon

Santa in Bart's fantasy

Josh Weinstein

Maggie Simpson

Liz Georges

(voice) / Additional Voices (voice) / Laughing Crowd (voice)

Chris Edgerly

Himself

Billy Corgan

Additional Voices (voice) / (voice) / Zombie Nurse

Karl Wiedergott*

Herself

D'Arcy

Norbert Gastell

Himself

Jimmy Chamberlin

Himself

Thurston Moore

Dr. Hibbert (voice) / (voice) / Narrator (voice)

Kevin Michael Richardson

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Himself

Lee Ranaldo

Sandra Schwittau

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

Himself

Steve Shelley

Himself

James Iha

Bernice Hibbert (voice) / (voice) / Court Bailiff (voice)

Dawnn Lewis

Orson Welles (voice) / (voice) / City Inspector (voice)

Maurice LaMarche

Artie Ziff (voice) / Llewellyn Sinclair (voice) / Enrico Irritazio (voice)

Jon Lovitz

Kumiko Albertson (voice) / Truth-Anne (voice) / (voice)

Jenny Yokobori

Lewis Clark (voice) / Janey Powell (voice) / Janine Powell (voice)

Kimberly Brooks

Julio Franco (voice) / Julio (voice) / (voice)

Tony Rodriguez

Hyman Krustofsky (voice)

Jackie Mason

Jacques (voice) / Hank Scorpio (voice) / Slick Manager (voice)

Albert Brooks

Maude Flanders (voice) / Helen Lovejoy (voice) / Miss Hoover (voice)

Marcia Mitzman Gaven

Constance Harm (voice) / Judge Harm (voice) / Judge Constance Harm (voice)

Jane Kaczmarek

Rayshelle Peyton (voice)

Kerry Washington

Milhouse Van Houten (voice)

Kelly Macleod

Weasel (voice) / Martin Prince / Photography Club Member #3

Jo Ann Harris

Manjula Nahasapeemapetilon (voice)

Jan Hooks

Mrs. Butterworth (voice) / Nurse (voice) / Ms. Myles (voice)

Valerie Harper

Bumblebee Man (voice) / (voice) / Gambling Old Man (voice)

Eric Lopez

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard K. Duff VIII

Stacy Keach

Murphy (voice) / I.N.S. Agent (voice) / Dana Gould (voice)

Dana Gould

Dr. Lionel Budgie (voice) / Nigel (voice) / Mason Fairbanks (voice)

Michael York

Sarah Wiggum (voice)

Megan Mullally

Stephen Hawking (voice)

Stephen Hawking

Akira Kurosawa (voice) / George Takei (voice) / Wink - The Game Show Host (voice)

George Takei

Victor Kleskow (voice) / Dr. Jessup (voice) / JJ Gruff (voice)

J.K. Simmons

Axel (voice) / Bull (voice) / Balfalmagog (voice)

Jonathan Lipow