Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Lisa Simpson (voice)

Yeardley Smith

Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz

Nancy Cartwright

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Himself

Paul McCartney

Erin

Christina Ricci

Himself

Peter Frampton

Ms. Dare / Gwen / Homer's Cousin's Wife (voice)

Tress MacNeille

Hollis Hurlbut

Donald Sutherland

Fat Tony (voice) / Fit-Fat Tony (voice) / Gordus Antonius (voice)

Joe Mantegna

Mona Simpson (voice)

Glenn Close

Chester J. Lampwick

Kirk Douglas

Don Brodka

Lawrence Tierney

Himself

Tom Kite

Himself

Paul Anka

Sideshow Bob (voice)

Kelsey Grammer

himself

Tito Puente

Himself

Bob Newhart

Woman on Phone

Joan Kenley

Bill Gannon

Harry Morgan

Herself

Kim Gordon

Himself

Mickey Rooney

Herself

Suzanne Somers

Milhouse (voice) / Milhouse / Jimbo (voice)

Pamela Hayden

himself

Buzz Aldrin

Herself

Linda McCartney

Guest Voice

Daryl Gates

MacArthur Parker

Jeff Goldblum

Colonel Leslie Hapablap

R. Lee Ermey

Lionel Hutz / Troy McClure / Lyle Lanley

Phil Hartman

Roger Meyers Jr.

Alex Rocco

Himself

B-Real

Edna Krabappel (voice) / Edna Krabappel / Ms. Melon (voice)

Marcia Wallace

Lead Vocalist

George Balmaseda

Hong Kong Doctor

Jim Lau

Lunchlady Doris

Doris Grau

Himself

DJ Muggs

Rod Flanders (voice) / Helen Lovejoy (voice) / Luann Van Houten (voice)

Maggie Roswell

Martin Prince (voice) / Sherri / Martin

Russi Taylor

Himself

Sen Dog

(voice) / Santa's Little Helper / various animals (voice)

Frank Welker

The Amendment

Jack Sheldon

Santa in Bart's fantasy

Josh Weinstein

Maggie Simpson

Liz Georges

Himself

Billy Corgan

(voice) / Additional Voices (voice) / Bum #1

Karl Wiedergott*

Herself

D'Arcy

Norbert Gastell

Himself

Jimmy Chamberlin

Security Guard / Burns' Cellmate / many minor characters

Kevin Michael Richardson

Himself

Thurston Moore

Sandra Schwittau

Army recruiter 2 / Billy / others characters (voice)

Maurice LaMarche

Himself

Lee Ranaldo

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Himself

Steve Shelley

Artie Ziff / Llewellyn Sinclair / other minor characters.

Jon Lovitz

Himself

James Iha

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

(voice) / Boat Owner / Neighborhood Meeting Notification (voice)

Chris Edgerly

Bernice Hibbert (voice) / (voice) / Mrs. McBride (voice)

Dawnn Lewis

Hyman Krustofsky (voice)

Jackie Mason

Jacques / Hank Scorpio / others characters (voice)

Albert Brooks

Constance Harm (voice) / Judge Harm (voice)

Jane Kaczmarek

Manjula (voice)

Jan Hooks

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard Duff (voice)

Stacy Keach

Murphy (voice) / Dana Gould (voice)

Dana Gould

Dr. Lionel Budgie (voice) / Mason Fairbanks (voice) / Nigel (voice)

Michael York

Stephen Hawking (voice)

Stephen Hawking

Akira Kurosawa (voice)

George Takei

Victor Kleskow (voice)

J.K. Simmons

Girl (voice) / Weasel #2 / Richard

Jo Ann Harris

Director

Pete Michels

Director

Neil Affleck

Director

Chuck Sheetz

Director

David Silverman

Director

Lauren MacMullan

Director

Dominic Polcino

Director

Swinton O. Scott III

Director

Rich Moore

Director

Raymond S. Persi

Director

Mark Kirkland

Director

Jennifer Moeller

Director

Mike B. Anderson

Director

Michael Polcino