Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bart Simpson/Nelson Muntz/Todd Flanders/Ralph Wiggum/Kearney

Nancy Cartwright

Lisa Marie Simpson

Yeardley Smith

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Himself

Leonard Nimoy

Herself

Brooke Shields

Maggie Simpson

Elizabeth Taylor

Himself

Adam West

Sideshow Raheem

Michael Carrington

Herself

Joyce Brothers

Edna Krabappel (voice) / Crowd (voice) / Edna Krabappel

Marcia Wallace

Himself

Tom Jones

Laura Powers

Sara Gilbert

himself

David Crosby

Himself

Bob Hope

Himself

Linda Ronstadt

Milhouse Van Houten (voice) / Milhouse (voice) / Milhouse Van Houten

Pamela Hayden

Himself

Johnny Carson

Lunchlady Doris (voice) / Ice cream lady (voice) / Shotgun Pete's Receptionist (voice)

Doris Grau

Ruth Powers

Pamela Reed

Troy McClure (voice) / Lionel Hutz (voice) / Lionel Hutz

Phil Hartman

Weasel (voice) / Martin Prince / Photography Club Member #3

Jo Ann Harris

Agnes Skinner (voice) / (voice) / Dolph (voice)

Tress MacNeille

Herself

Bette Midler

Artie Ziff (voice) / Llewellyn Sinclair (voice) / Enrico Irritazio (voice)

Jon Lovitz

Sylvia Winfield / Woman in Restaurant / Woman Looking to Buy House / Abbey's Sister / Abbey

Maggie Roswell

Himself

Barry White

Himself

Luke Perry

Martin Prince (voice) / Martin Prince / Sherri

Russi Taylor

Amber Dempsey

Lona Williams

Additional Voices (voice) / (voice) / Zombie Nurse

Karl Wiedergott*

(voice) / Additional Voices (voice) / Laughing Crowd (voice)

Chris Edgerly

Himself

Hugh Hefner

Norbert Gastell

Himself

Anthony Kiedis

Elisabeth Volkmann

Himself

Flea

Dr. Hibbert (voice) / (voice) / Narrator (voice)

Kevin Michael Richardson

Sandra Schwittau

Himself

Chad Smith

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Sabine Bohlmann

Himself

Arik Marshall

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

Fat Tony (voice) / Fat Tony / Fat Tony's Former Father (voice)

Joe Mantegna

Bernice Hibbert (voice) / (voice) / Court Bailiff (voice)

Dawnn Lewis

Orson Welles (voice) / (voice) / City Inspector (voice)

Maurice LaMarche

Sideshow Bob (voice)

Kelsey Grammer

Kumiko Albertson (voice) / Truth-Anne (voice) / (voice)

Jenny Yokobori

Lewis Clark (voice) / Janey Powell (voice) / Janine Powell (voice)

Kimberly Brooks

Mona Simpson (voice)

Glenn Close

Julio Franco (voice) / Julio (voice) / (voice)

Tony Rodriguez

Hyman Krustofsky (voice)

Jackie Mason

Jacques (voice) / Hank Scorpio (voice) / Slick Manager (voice)

Albert Brooks

Maude Flanders (voice) / Helen Lovejoy (voice) / Miss Hoover (voice)

Marcia Mitzman Gaven

Constance Harm (voice) / Judge Harm (voice) / Judge Constance Harm (voice)

Jane Kaczmarek

Rayshelle Peyton (voice)

Kerry Washington

Milhouse Van Houten (voice)

Kelly Macleod

Manjula Nahasapeemapetilon (voice)

Jan Hooks

Mrs. Butterworth (voice) / Nurse (voice) / Ms. Myles (voice)

Valerie Harper

Bumblebee Man (voice) / (voice) / Gambling Old Man (voice)

Eric Lopez

Baboons (voice) / Santa's Little Helper / Mr. Teeny

Frank Welker

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard K. Duff VIII

Stacy Keach

Murphy (voice) / I.N.S. Agent (voice) / Dana Gould (voice)

Dana Gould

Dr. Lionel Budgie (voice) / Nigel (voice) / Mason Fairbanks (voice)

Michael York

Sarah Wiggum (voice)

Megan Mullally

Stephen Hawking (voice)

Stephen Hawking

Akira Kurosawa (voice) / George Takei (voice) / Wink - The Game Show Host (voice)

George Takei

Victor Kleskow (voice) / Dr. Jessup (voice) / JJ Gruff (voice)

J.K. Simmons

Axel (voice) / Bull (voice) / Balfalmagog (voice)

Jonathan Lipow