Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz

Nancy Cartwright

Lisa Marie Simpson

Yeardley Smith

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Himself

Leonard Nimoy

Herself

Brooke Shields

Maggie Simpson

Elizabeth Taylor

Himself

Adam West

Sideshow Raheem

Michael Carrington

Herself

Joyce Brothers

Edna Krabappel (voice) / Edna Krabappel / Ms. Melon (voice)

Marcia Wallace

Laura Powers

Sara Gilbert

himself

David Crosby

Himself

Bob Hope

Himself

Tom Jones

Himself

Linda Ronstadt

Ms. Dare / Gwen / Homer's Cousin's Wife (voice)

Tress MacNeille

Milhouse (voice) / Milhouse / Jimbo (voice)

Pamela Hayden

Himself

Johnny Carson

Ice-Cream Lady

Doris Grau

Ruth Powers

Pamela Reed

Lionel Hutz / Troy McClure / Lyle Lanley

Phil Hartman

Girl (voice) / Weasel #2 / Richard

Jo Ann Harris

Herself

Bette Midler

Artie Ziff / Llewellyn Sinclair / other minor characters.

Jon Lovitz

Sylvia Winfield / Woman in Restaurant / Woman Looking to Buy House / Abbey's Sister / Abbey

Maggie Roswell

Himself

Barry White

Himself

Luke Perry

Martin Prince (voice) / Sherri / Martin

Russi Taylor

Amber Dempsey

Lona Williams

(voice) / Additional Voices (voice) / Bum #1

Karl Wiedergott*

Himself

Hugh Hefner

Norbert Gastell

Fat Tony (voice) / Fit-Fat Tony (voice) / Gordus Antonius (voice)

Joe Mantegna

Himself

Anthony Kiedis

Elisabeth Volkmann

Security Guard / Burns' Cellmate / many minor characters

Kevin Michael Richardson

Himself

Flea

Sandra Schwittau

Sideshow Bob (voice)

Kelsey Grammer

Himself

Chad Smith

Sabine Bohlmann

Army recruiter 2 / Billy / others characters (voice)

Maurice LaMarche

Himself

Arik Marshall

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

(voice) / Boat Owner / Neighborhood Meeting Notification (voice)

Chris Edgerly

Bernice Hibbert (voice) / (voice) / Mrs. McBride (voice)

Dawnn Lewis

Mona Simpson (voice)

Glenn Close

Hyman Krustofsky (voice)

Jackie Mason

Jacques / Hank Scorpio / others characters (voice)

Albert Brooks

Constance Harm (voice) / Judge Harm (voice)

Jane Kaczmarek

Manjula (voice)

Jan Hooks

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard Duff (voice)

Stacy Keach

Murphy (voice) / Dana Gould (voice)

Dana Gould

Dr. Lionel Budgie (voice) / Mason Fairbanks (voice) / Nigel (voice)

Michael York

Stephen Hawking (voice)

Stephen Hawking

Akira Kurosawa (voice)

George Takei

Victor Kleskow (voice)

J.K. Simmons

(voice) / Santa's Little Helper / various animals (voice)

Frank Welker

Director

Pete Michels

Director

Jim Reardon

Director

Neil Affleck

Director

Chuck Sheetz

Director

David Silverman

Director

Lauren MacMullan

Director

Dominic Polcino

Director

Swinton O. Scott III

Director

Rich Moore

Director

Raymond S. Persi

Director

Mark Kirkland

Director

Jennifer Moeller

Director

Mike B. Anderson

Director

Michael Polcino