Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz

Nancy Cartwright

Lisa Marie Simpson

Yeardley Smith

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Mindy Simmons

Michelle Pfeiffer

Himself

James Brown

Milhouse (voice) / Milhouse / Jimbo (voice)

Pamela Hayden

Stacy Lavelle

Kathleen Turner

Himself

Buzz Aldrin

Himself

Ernest Borgnine

Himself

James Woods

Ruth Powers

Pamela Reed

Molloy

Sam Neill

Sideshow Bob (voice)

Kelsey Grammer

Himself

Conan O'Brien

himself

George Harrison

Lionel Hutz / Troy McClure / Lyle Lanley

Phil Hartman

Himself

Robert Goulet

Ms. Dare / Gwen / Homer's Cousin's Wife (voice)

Tress MacNeille

Himself

James Taylor

Comedian

Michael Carrington

Narrorator

George Fenneman

Lunchlady Doris

Doris Grau

Edna Krabappel (voice) / Edna Krabappel / Ms. Melon (voice)

Marcia Wallace

himself

David Crosby

Himself

Gerry Cooney

Jim Reardon

Homer's Guardian Angel as Colonel Klink

Werner Klemperer

Alf Clausen

Jacques / Hank Scorpio / others characters (voice)

Albert Brooks

Seymour Skinner

James Campbell

Himself

Joey Ramone

Rod Flanders (voice) / Helen Lovejoy (voice) / Luann Van Houten (voice)

Maggie Roswell

John Swartzwelder

Martin Prince/Sherri/Terri/Girls/Woman on Parole Board

Russi Taylor

Apu

Michael Economou

Himself

Johnny Ramone

Jonathan Collier

Barney Gumble / Chief Wiggum

Shelby Grimm

Himself

Marky Ramone

Bill Canterbury

CJ Ramone

Christopher Ward

(voice) / Santa's Little Helper / various animals (voice)

Frank Welker

Homer Simpson (singing voice)

Don Jordan

Fat Tony (voice) / Fit-Fat Tony (voice) / Gordus Antonius (voice)

Joe Mantegna

David X. Cohen

Security Guard / Burns' Cellmate / many minor characters

Kevin Michael Richardson

The Be Sharps

The Dapper Dans

Army recruiter 2 / Billy / others characters (voice)

Maurice LaMarche

(voice) / Additional Voices (voice) / Bum #1

Karl Wiedergott*

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

(voice) / Boat Owner / Neighborhood Meeting Notification (voice)

Chris Edgerly

Artie Ziff / Llewellyn Sinclair / other minor characters.

Jon Lovitz

James Campbell

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

Bernice Hibbert (voice) / (voice) / Mrs. McBride (voice)

Dawnn Lewis

Mona Simpson (voice)

Glenn Close

Hyman Krustofsky (voice)

Jackie Mason

Seymour Skinner

Harry J. Campbell

Constance Harm (voice) / Judge Harm (voice)

Jane Kaczmarek

Barney Gumble/Chief Wiggum

Shelby Grimm

Manjula (voice)

Jan Hooks

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard Duff (voice)

Stacy Keach

Murphy (voice) / Dana Gould (voice)

Dana Gould

Dr. Lionel Budgie (voice) / Mason Fairbanks (voice) / Nigel (voice)

Michael York

Stephen Hawking (voice)

Stephen Hawking

Akira Kurosawa (voice)

George Takei

Victor Kleskow (voice)

J.K. Simmons

Girl (voice) / Weasel #2 / Richard

Jo Ann Harris

Director

Pete Michels

Director

Jim Reardon

Director

Neil Affleck

Director

Chuck Sheetz

Director

David Silverman

Director

Lauren MacMullan

Director

Dominic Polcino

Director

Swinton O. Scott III

Director

Rich Moore

Director

Raymond S. Persi

Director

Mark Kirkland

Director

Jennifer Moeller

Director

Mike B. Anderson

Director

Michael Polcino