Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz

Nancy Cartwright

Lisa Marie Simpson

Yeardley Smith

Edna Krabappel (voice) / Edna Krabappel / Ms. Melon (voice)

Marcia Wallace

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Himself

Paul Newman

Buck McCoy

Dennis Weaver

Milhouse Van Houten

Pamela Hayden

Himself

James Lipton

Stan Lee

Stan Lee

Constance Harm (voice) / Judge Harm (voice)

Jane Kaczmarek

Fat Tony (voice) / Fit-Fat Tony (voice) / Gordus Antonius (voice)

Joe Mantegna

Artie Ziff / Llewellyn Sinclair / other minor characters.

Jon Lovitz

Zelda

Olympia Dukakis

Himself

Richard Gere

Murphy (voice) / Dana Gould (voice)

Dana Gould

Himself

Michael Stipe

Himself

Trey Anastasio

Herself

Carmen Electra

Himself

Robert Pinsky

Garth Motherloving

Ben Stiller

Ms. Dare / Gwen / Homer's Cousin's Wife (voice)

Tress MacNeille

Pancho

Jess Harnell

Mrs. Bellamy

Frances Sternhagen

Herself

Judith Owen

Raymond J. Johnson Jr.

Bill Saluga

Greta Wolfcastle

Reese Witherspoon

Himself

Jon Fishman

Himself

Peter Buck

Donkey

John Kassir

Himself

Wolfgang Puck

Tough Street Dog / Mean Zoo Animals / Frank the Wonder Horse

Frank Welker

Himself

Mike Gordon

Gabriel

Delroy Lindo

Himself

Mike Mills

Himself

Page McConnell

Singer

Brian Hamilton

Miss Hoover

Marcia Mitzman Gaven

Gloria

Julia Louis-Dreyfus

Martin Prince (voice) / Sherri / Martin

Russi Taylor

(voice) / Additional Voices (voice) / Bum #1

Karl Wiedergott*

Singer

Charity James

Rod Flanders (voice) / Helen Lovejoy (voice) / Luann Van Houten (voice)

Maggie Roswell

Akira Kurosawa (voice)

George Takei

Lionel Hutz / Troy McClure / Lyle Lanley

Phil Hartman

Norbert Gastell

Himself

Pierce Brosnan

Himself

Matthew Perry

Security Guard / Burns' Cellmate / many minor characters

Kevin Michael Richardson

Sandra Schwittau

Sideshow Bob (voice)

Kelsey Grammer

Army recruiter 2 / Billy / others characters (voice)

Maurice LaMarche

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

(voice) / Boat Owner / Neighborhood Meeting Notification (voice)

Chris Edgerly

Bernice Hibbert (voice) / (voice) / Mrs. McBride (voice)

Dawnn Lewis

Mona Simpson (voice)

Glenn Close

Hyman Krustofsky (voice)

Jackie Mason

Jacques / Hank Scorpio / others characters (voice)

Albert Brooks

Manjula (voice)

Jan Hooks

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard Duff (voice)

Stacy Keach

Dr. Lionel Budgie (voice) / Mason Fairbanks (voice) / Nigel (voice)

Michael York

Stephen Hawking (voice)

Stephen Hawking

Victor Kleskow (voice)

J.K. Simmons

Girl (voice) / Weasel #2 / Richard

Jo Ann Harris

Director

Pete Michels

Director

Neil Affleck

Director

Chuck Sheetz

Director

David Silverman

Director

Lauren MacMullan

Director

Dominic Polcino

Director

Swinton O. Scott III

Director

Rich Moore

Director

Raymond S. Persi

Director

Mark Kirkland

Director

Jennifer Moeller

Director

Mike B. Anderson

Director

Michael Polcino