Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz

Nancy Cartwright

Lisa Marie Simpson

Yeardley Smith

Edna Krabappel (voice) / Crowd (voice) / Edna Krabappel

Marcia Wallace

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Himself

Paul Newman

Buck McCoy

Dennis Weaver

Milhouse Van Houten

Pamela Hayden

Himself

James Lipton

Stan Lee

Stan Lee

Constance Harm (voice) / Judge Harm (voice) / Judge Constance Harm (voice)

Jane Kaczmarek

Fat Tony (voice) / Fat Tony / Fat Tony's Former Father (voice)

Joe Mantegna

Artie Ziff (voice) / Llewellyn Sinclair (voice) / Enrico Irritazio (voice)

Jon Lovitz

Zelda

Olympia Dukakis

Himself

Richard Gere

Murphy (voice) / I.N.S. Agent (voice) / Dana Gould (voice)

Dana Gould

Himself

Michael Stipe

Himself

Trey Anastasio

Herself

Carmen Electra

Himself

Robert Pinsky

Garth Motherloving

Ben Stiller

Pancho

Jess Harnell

Mrs. Bellamy

Frances Sternhagen

Herself

Judith Owen

Raymond J. Johnson Jr.

Bill Saluga

Greta Wolfcastle

Reese Witherspoon

Himself

Jon Fishman

Himself

Peter Buck

Donkey

John Kassir

Himself

Wolfgang Puck

Tough Street Dog / Mean Zoo Animals / Frank the Wonder Horse

Frank Welker

Agnes Skinner (voice) / (voice) / Dolph (voice)

Tress MacNeille

Himself

Mike Gordon

Gabriel

Delroy Lindo

Himself

Mike Mills

Himself

Page McConnell

Singer

Brian Hamilton

Maude Flanders (voice) / Helen Lovejoy (voice) / Miss Hoover (voice)

Marcia Mitzman Gaven

Gloria

Julia Louis-Dreyfus

Martin Prince (voice) / Martin Prince / Sherri

Russi Taylor

Additional Voices (voice) / (voice) / Zombie Nurse

Karl Wiedergott*

Singer

Charity James

Maude Flanders (voice) / Luann Van Houten (voice) / Helen Lovejoy (voice)

Maggie Roswell

Akira Kurosawa (voice) / George Takei (voice) / Wink - The Game Show Host (voice)

George Takei

(voice) / Additional Voices (voice) / Laughing Crowd (voice)

Chris Edgerly

Norbert Gastell

Himself

Pierce Brosnan

Himself

Matthew Perry

Dr. Hibbert (voice) / (voice) / Narrator (voice)

Kevin Michael Richardson

Sandra Schwittau

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

Sideshow Bob (voice)

Kelsey Grammer

Troy McClure (voice) / Lionel Hutz (voice) / Lionel Hutz

Phil Hartman

Bernice Hibbert (voice) / (voice) / Court Bailiff (voice)

Dawnn Lewis

Orson Welles (voice) / (voice) / City Inspector (voice)

Maurice LaMarche

Kumiko Albertson (voice) / Truth-Anne (voice) / (voice)

Jenny Yokobori

Lewis Clark (voice) / Janey Powell (voice) / Janine Powell (voice)

Kimberly Brooks

Mona Simpson (voice)

Glenn Close

Julio Franco (voice) / Julio (voice) / (voice)

Tony Rodriguez

Hyman Krustofsky (voice)

Jackie Mason

Jacques (voice) / Hank Scorpio (voice) / Slick Manager (voice)

Albert Brooks

Rayshelle Peyton (voice)

Kerry Washington

Milhouse Van Houten (voice)

Kelly Macleod

Lunchlady Doris (voice) / Ice cream lady (voice) / Shotgun Pete's Receptionist (voice)

Doris Grau

Weasel (voice) / Martin Prince / Photography Club Member #3

Jo Ann Harris

Manjula Nahasapeemapetilon (voice)

Jan Hooks

Mrs. Butterworth (voice) / Nurse (voice) / Ms. Myles (voice)

Valerie Harper

Bumblebee Man (voice) / (voice) / Gambling Old Man (voice)

Eric Lopez

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard K. Duff VIII

Stacy Keach

Dr. Lionel Budgie (voice) / Nigel (voice) / Mason Fairbanks (voice)

Michael York

Sarah Wiggum (voice)

Megan Mullally

Stephen Hawking (voice)

Stephen Hawking

Victor Kleskow (voice) / Dr. Jessup (voice) / JJ Gruff (voice)

J.K. Simmons

Axel (voice) / Bull (voice) / Balfalmagog (voice)

Jonathan Lipow