Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz

Nancy Cartwright

Lisa Marie Simpson

Yeardley Smith

Edna Krabappel (voice) / Crowd (voice) / Edna Krabappel

Marcia Wallace

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Himself

Paul Newman

Buck McCoy

Dennis Weaver

Milhouse Van Houten

Pamela Hayden

Himself

James Lipton

Stan Lee

Stan Lee

Constance Harm (voice) / Judge Harm (voice)

Jane Kaczmarek

Fat Tony (voice) / Gordus Antonius (voice)

Joe Mantegna

Llewellyn Sinclair (voice) / Artie Ziff (voice) / Enrico Irritazio (voice)

Jon Lovitz

Zelda

Olympia Dukakis

Himself

Richard Gere

Murphy (voice) / Dana Gould (voice) / I.N.S. Agent (voice)

Dana Gould

Himself

Michael Stipe

Himself

Trey Anastasio

Herself

Carmen Electra

Himself

Robert Pinsky

Garth Motherloving

Ben Stiller

Pancho

Jess Harnell

Mrs. Bellamy

Frances Sternhagen

Herself

Judith Owen

Raymond J. Johnson Jr.

Bill Saluga

Greta Wolfcastle

Reese Witherspoon

Himself

Jon Fishman

Himself

Peter Buck

Donkey

John Kassir

Himself

Wolfgang Puck

Monkeys / Princess (voice) / Executive Vice-President (voice)

Frank Welker

Agnes Skinner (voice) / Dolph (voice) / (voice)

Tress MacNeille

Himself

Mike Gordon

Gabriel

Delroy Lindo

Himself

Mike Mills

Himself

Page McConnell

Singer

Brian Hamilton

Helen Lovejoy (voice) / Maude Flanders (voice) / Miss Hoover (voice)

Marcia Mitzman Gaven

Gloria

Julia Louis-Dreyfus

Martin Prince (voice) / Martin Prince / Sherri

Russi Taylor

Additional Voices (voice) / (voice) / Prisoners

Karl Wiedergott*

Singer

Charity James

Maude Flanders (voice) / Luann Van Houten (voice) / Helen Lovejoy (voice)

Maggie Roswell

Akira Kurosawa (voice) / Wink - The Game Show Host (voice) / Waiter (voice)

George Takei

(voice) / Additional Voices (voice) / Laughing Crowd (voice)

Chris Edgerly

Norbert Gastell

Himself

Pierce Brosnan

Himself

Matthew Perry

Dr. Hibbert (voice) / Narrator (voice) / Jay G (voice)

Kevin Michael Richardson

Sandra Schwittau

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Sideshow Bob (voice)

Kelsey Grammer

Troy McClure (voice) / Lionel Hutz (voice) / Lionel Hutz

Phil Hartman

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

Bernice Hibbert (voice) / (voice) / Cannabis Influencer (voice)

Dawnn Lewis

Orson Welles (voice) / (voice) / Chef Naziwa

Maurice LaMarche

Mona Simpson (voice)

Glenn Close

Kumiko Albertson (voice) / Truth-Anne (voice) / Band Student (voice)

Jenny Yokobori

Hyman Krustofsky (voice)

Jackie Mason

Jacques (voice) / Hank Scorpio (voice) / Tab Spangler

Albert Brooks

Julio Franco (voice) / Julio (voice) / Audience

Tony Rodriguez

Lewis Clark (voice) / Janine Powell (voice) / Kindergartener (voice)

Kimberly Brooks

Lunchlady Doris (voice) / Ice cream lady (voice) / Della (voice)

Doris Grau

Susan / Collette the Waitress (voice) / Weasel #2

Jo Ann Harris

Manjula Nahasapeemapetilon (voice)

Jan Hooks

Rayshelle Peyton (voice)

Kerry Washington

Backstage Mom (voice) / Mrs. Butterworth (voice) / Old Lady (voice)

Valerie Harper

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard Duff (voice)

Stacy Keach

Dr. Lionel Budgie (voice) / Nigel (voice) / Clayton (voice)

Michael York

Bumblebee Man (voice) / Lisa's Student (voice) / Gambling Old Man (voice)

Eric Lopez

Stephen Hawking (voice)

Stephen Hawking

Sarah Wiggum (voice)

Megan Mullally

J. Jonah Jameson (voice) / Victor Kleskow (voice) / Tabloid Editor (voice)

J.K. Simmons